Etifoxine

Product Name: Etifoxine
CAS No.: 21715-46-8
Chemical Name: Etifoxine
Synonyms: 36-801;Etifoxin;Etifoxine;HOE-36801;HOE-36-801;etafenoxine;Etifoxine (HOE36801);6-chloro-N-ethyl-4-methyl-4-phenyl-3,1-benzoxazin-2-amine;2-Ethylamino-6-chloro-4-methyl-4-phenyl-4H-3,1-benzoxazine;6-Chloro-2-ethylamino-4-methyl-4-phenyl-4H-3,1-benzoxazine
CBNumber: CB7875113
Molecular Formula: C17H17ClN2O
Formula Weight: 300.78
MOL File: 21715-46-8.mol

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Etifoxine Property

Melting point:: 90-92℃
Boiling point:: 421.2±55.0 °C(Predicted)
Density: 1.1716 (rough estimate)
vapor pressure: 0-1Pa at 20-25℃
refractive index: 1.5800 (estimate)
storage temp.: Store at -20°C
solubility: DMSO:60.0(Max Conc. mg/mL);199.47(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);99.74(Max Conc. mM)
DMF:PBS (pH 7.2) (1:8):0.1(Max Conc. mg/mL);0.33(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);66.49(Max Conc. mM)
form: Solid:particulate/powder
pka: 4.89±0.40(Predicted)
LogP: 4.09-4.52 at 21-25℃ and pH7

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Safety

Toxicity: LD50 orally in mice: 12 g/kg (Hoffmann)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H401Toxic to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 15999
Product name: Etifoxine
Purity: ≥98%
Packaging: 5mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 15999
Product name: Etifoxine
Purity: ≥98%
Packaging: 10mg
Price: $129
Updated: 2024/03/01

Cayman Chemical

Product number: 15999
Product name: Etifoxine
Purity: ≥98%
Packaging: 25mg
Price: $296
Updated: 2024/03/01

Cayman Chemical

Product number: 15999
Product name: Etifoxine
Purity: ≥98%
Packaging: 50mg
Price: $546
Updated: 2024/03/01

ChemScene

Product number: CS-1104
Product name: Etifoxine
Purity: 99.87%
Packaging: 100mg
Price: $610
Updated: 2021/12/16

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Etifoxine Chemical Properties,Usage,Production

Originator

Circupon,Troponwerke,W. Germany

Definition

ChEBI: Etifoxine is a benzoxazine.

Manufacturing Process

30 parts of 1-(3'-hydroxyphenyl)-2-(N-benzylaminomethyl)-ethan-1-one are mixed with 100 parts of pyridine and 30 parts of pivalic anhydride and dissolved while warming. After heating for 1 hour under reflux, the acylation is complete. After concentrating the reaction solution, the product is precipitated from acetone/ether. Yield: 96.4% of 1-(3'-pivaloyloxyphenyl)-2- (N-benzylaminomethyl)-ethan-1-one.
3 parts of palladium/charcoal (10% strength) are prehydrogenated in water, thereafter 10 parts of 1-(3'-pivaloyloxyphenyl)-2-(N-benzylaminoethyl)-ethan- 1-one, dissolved in a 10-fold amount of water, are added dropwise at room temperature and hydrogenation is carried out until 1 mol of hydrogen has been taken up. After filtering off the catalyst, a further 3 parts of palladium/charcoal are added and hydrogenation is carried out until a further mol of hydrogen has been taken up. The catalyst is separated off and after removal of the solvent the hydrogenation product is reprecipitated from acetone/petroleum ether and from methanol/ether until it is pure according to thin layer chromatography. Yield: 38.8% of 1-(3'-pivaloyloxyphenyl)-2- ethylaminoethanol-1 hydroxide, melting point 208°C to 209°C.

Therapeutic Function

Tranquilizer

Etifoxine Preparation Products And Raw materials

Raw materials

Preparation Products

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Etifoxine Suppliers

China 57 Europe 1 India 1 South Korea 1 United States 10 Global 70

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 19892
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 52927
Advantage: 58

21715-46-8, EtifoxineRelated Search:

2-amino-5-chloro-diphenyl methanol O-ISOPROPYLISOUREA HYDROCHLORIDE N,N-didemethylchlordimeform O-Ethylisourea hydrochloride demethylchlordimeform O-Methylisourea hydrochloride Etifoxine ISOPROPYL FORMIMIDATE HYDROCHLORIDE 4H-BENZO[D][1,3]OXAZIN-2-AMINE

etafenoxine

36-801

6-Chloro-2-ethylamino-4-methyl-4-phenyl-4H-3,1-benzoxazine

Etifoxin

HOE-36801

HOE-36-801

2-Ethylamino-6-chloro-4-methyl-4-phenyl-4H-3,1-benzoxazine

Etifoxine

4H-3,1-Benzoxazin-2-amine, 6-chloro-N-ethyl-4-methyl-4-phenyl-

Etifoxine (HOE36801)

6-chloro-N-ethyl-4-methyl-4-phenyl-3,1-benzoxazin-2-amine

21715-46-8